Phospholipase C-epsilon pathway
| PAG Title | Phospholipase C-epsilon pathway |
| PAG ID | WIG000406 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium signalling. Receptors coupling to Gs stimulate AC, resulting in elevated cAMP levels and activation of Epac1. Epac1 then catalyses GTP-loading on Rap2B, which leads to PLC-e activation. The proposed pathway may involve additional signalling components to attain PLC stimulation. The action of cAMP seems to be independent of PKA; Instead, the cAMP-activated Rap-GEF Epac seems to serve as a cAMP effector, inducing GTP loading and, hence, activation of Rap2B, which then leads to specific activation of PLC-e, which has been shown to interact with Rap GTPases. It is an attractive hypothesis, therefore, that the Rap-dependent PLC and calcium signalling pathway reported here is not restricted to Gs-and AC-coupled receptors, such as the b2-AR and the prostanoid receptor, but could be used by other receptors as well. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,096 |
| Information Content | Rich |
| Other IDs | M5576 |
| Base PAG ID | WIG000406 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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